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Nobuo Tanaka. Journal of Chromatography A, 1217 (2010) 857
doi:10.1016/j.chroma.2009.11.067

Phenomenex 2018色谱成品指南汉语版正式出版

henomenex推出全新Luna Omega HILIC色谱柱 提升三磷酸腺苷物质抽离程度

Editorial on “The challenges of the analysis of basic compounds by
high performance liquid chromatography: Some possible approaches for
improved separations
” by D.V. McCalley

美利坚联邦合众国加利福尼亚州,Toland斯(2018年七月13日)宣布消息——作为抽离科学领域具备先进研究开发格局和生产总量的芸芸众生盛名集团,Phenomenex企标发行其2018版全线付加物及服务指南。那本455页的手册蕴涵了包括:HPLC/UHPLC液相色谱柱,气相色谱柱,制备柱和样本前管理成品在内的店肆全线付加物。除此而外,诸如全新SecurityCAP™
LC 溶剂安全成品以致新型LunaOmega分析柱等多款用于实验室的新付加物也展现在该新版色谱产物指南开中学。

Phenomenex 公司二月18日公告推出意气风发种新的卢纳Omega色谱柱,用于亲水效率色谱(HILIC)的糖解析。 Luna Omega
SUGAKoleos特地陈设用来从食品,果汁和药品,举个例子牛奶,动物饲料,味美思酒,苏打水,水果和片剂那么些基质中分别和分析生物素。新型的LunaOmega
SUGAR固定相富含酰胺多元醇,带接头的氨基和极性封端,它们一同发挥效能,通过卓有成效的相互影响机制协同推动更加大的极性保留。通过将这种HILIC固定相黏合到热改性的全多孔颗粒平台上制作而成的全新色谱柱,与市情上幸存产品比较,能够提供更加好的分开本领,越来越高的谐和,越来越高的再次出现性和越来越快的分析时间。

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新版色谱产物指南同期具有在线电子版以至全彩色印排版供剖析行家选拔。电子版手册满含高水平线上研究探讨会技艺资源,丰裕的网络工具,能够使客商获得全天候的能力扶植并万分方便、迅速的找到所需使用、色谱柱以致多数零装配零件成品。近年来多样语言版本的新版手册已在各个国家陆陆续续发行。

Phenomenex全世界成品经营贩卖高等经营Simon Lomas解释说:“大家开垦了Luna Omega
SUGA奥迪Q5,以支持那贰个在保存时间转移,柱寿命不足,运营时刻长,特异性差和高极性化合物保留率低级方面苦苦挣扎的客户。”“使用这种新型HPLC
/ UHPLC
HILIC色谱柱和简化的流淌相系统,客商未来能够更轻便,越来越好地分离单糖,二糖和低聚糖。”

HPLC columns have been continuously improved duringthe last forty years,
both in terms of their kinetic performance based on thereduction of
particle size of packing materials and also in their chemicalproperties.
The so-called silanol effect on silicabased phases, however, hasstill
been one of the major topics of chromatographic studies even after
thedevelopment of advanced stationary phases that were supposed to
providesymmetrical peaks for amines. The performance of an HPLC column
for theseparation of basic compounds is of much practical importance,
because manypharmaceuticals possess basic functionalities.

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为了保证高重复性,每个卢纳 Omega
SUGA福睿斯色谱柱均经过以糖测验为宗旨的严刻的身分调节流程认证。那确定保障了这种新媒质适用于常用的检查评定项目,比如大切诺基I,ELSD和MS。除了选用性和颗粒质量优势外,Phenomenex针对LunaOmega
SUGAXC90还开辟了少年老成套简化的运维条件。通过专一于仅使用氯化钙和水作为流动相的HILIC分离,新的色谱柱能够打败缓冲强度不近似,高pH值,峰值禁止,长日子的缓冲液开辟时间以致大概破坏糖分离的其余流动相的一丰富多彩主题材料。另一个便宜是流动相中高含量的正丁腈可用于减少忧愁,它能够使非极性化合物和污染物在运维开始的一段时代就被迫退出。

    Prof. David McCalley has been studying various aspectsof silanol
effects on the elution of basic compounds from stationary phases
forreversed-phase HPLC since the early 1980s until today. In fact, his
interest inchromatography began with gas rather than liquid phase
separations, workingwith glass capillary columns, and their application
to the analysis of sterolsas pollution indicators in environmental
samples. In those days, pyrex glasscolumns had to be drawn from a 1m
length of thick-walled glass tube,deactivated and coated, all by the
user, employing techniques that required someconsiderable patience and
dexterity. He still retains an active interest in gaschromatography, and
his research group was the first to identify (usingGC-negative chemical
ionization mass spectrometry) the presence of pollutantestrogens in the
River Thames in 2001. These compounds have been shown to beresponsible
for sex changes and sterility in male fish. This work attractedmuch
attention in the international news media such as the BBC and
theFinancial Times due to its perceived connections with human fertility
[1].

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文章来源:仪器消息网

    He began his studies in HPLC with the analysis ofalkaloids in the
early 1980s, being intrigued as to why some columns yielded goodpeak
shapes, while others showed broad tailing peaks or even
irreversibleadsorption of the same solutes. Since then, he has published
more than thirtypapers on subjects related to the secondary retention
processes inreversed-phase HPLC and silanol effects. His interests
included every aspect ofthese effects, including the influence of
stationary phase structure as well asthe probe compounds used, including
base strength (pKa values) and stericfactors, the effects of elution
conditions (type of organic modifier, itsconcentration, temperature,
buffer type, pH and flow rate of mobile phase), theeffect of sample mass
and overloading on the appearance of the effects. Hisinvestigations
concerning the overloading of ionized compounds have shown it tobe a
particularly nefarious problem that has not been solved by
theintroduction of the new Type B silica stationary phases. The
mechanism ofoverloading remains intriguing and is of much current
interest, as evidenced bythe dozens of recent publications by Prof.
Georges Guiochon in the journal onthis subject. He has also reported
characterization methods for stationary phasesand interpreted the
results of these evaluations using chemometric procedures.

The new guide is available online or in a full-color print version.
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in key geographic areas.

    Recently Dr. McCalley has been working oncharacterization of a
broader range of HPLC columns and chromatographicphenomena, including
new types of chromatographic support (small-sized silicaparticles,
hybrid materials, superficially porous particles, and
monolithiccolumns), HILIC stationary phases, and retention processes in
ultrahighpressure LC. He feels privileged to have published some of this
work incollaboration with a number of the most distinguished researchers
in LC. Hiswork is always related to the fundamentals of liquid
chromatography, and is ofmuch importance.

    These are the reasons why the author has been invitedto write this
review article, and why the subject will be of much interest toJournal
of Chromatography A readers. In this article he mainly addressed
theissue of how to obtain optimum results in the separation of basic
compounds. Itwill help readers interested in separation of basic
substances, orpharmaceuticals in general. The readers will get both
fundamental and advancedknowledge of the materials and conditions for
the separation of basiccompounds.

    Dr. McCalley loveshot springs,particularly those inJapanwhere he can
use some of his Japanese vocabulary talking with his neighbors inhot
waters. He feels very fortunate in having been able to visit parts of
theworld through his work that he would never have seen otherwise, and
has giveninvited lectures in the last year in places as diverse
asLondon,Cork,Dresden,Marseille,Baltimore, andKyoto. He must be a good
traveler, havingcuriosity in every aspect of life. He is a good organist
and pianist lovingespecially Bach and Art Tatum, and once considered
music as a career. I hope readerswill enjoy this article, and understand
from it how to deal with the separationof basic substances. I also hope
Dr. McCalley will continue to extend his workelucidating the
fundamentals of chromatography in a practical sense.

Reference [1] .

Kyoto,Japan                                                           NobuoTanaka

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